Chronic high-fat diet decreased detrusor mitochondrial respiration and increased nerve-mediated contractions.
Shelby A PowersTerence E RyanElena S PakMatthew O FraserJoseph M McClungJohanna L HannanPublished in: Neurourology and urodynamics (2019)
Chronic HFD increased adiposity, lead to more frequent voiding, and enhanced EFS-mediated detrusor contractions. Mitochondrial respiration was decreased and H2 O 2 emission increased following HFD. Further research is required to determine if alterations in mitochondrial function could play a role in the development of HFD-induced bladder dysfunction.