Population pharmacokinetics of subcutaneous C1-inhibitor for prevention of attacks in patients with hereditary angioedema.
Dipti PawaskarMichael A TortoriciBruce L ZurawTimothy CraigMarco CicardiHilary LonghurstH Henry LiWilliam R LumryInmaculada Martinez-SaguerJoshua JacobsJonathan A BernsteinMarc A RiedlConstance H KatelarisPaul K KeithAnnette FeussnerJagdev SidhuPublished in: Clinical and experimental allergy : journal of the British Society for Allergy and Clinical Immunology (2018)
Twice-weekly bodyweight-adjusted dosing of C1-INH (SC) exhibits linear pharmacokinetics and dose-dependent increases in Ctrough levels at each dosing interval. In this analysis, SC dosing led to maintenance of higher Ctrough levels than IV dosing.
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