Selective T-cell depletion targeting CD45RA reduces viremia and enhances early T-cell recovery compared with CD3-targeted T-cell depletion.

Brandon M TriplettBrad MullerGuolian KangYing LiShane J CrossJoseph MoenLea CunninghamWilliam JanssenEwelina MamcarzDavid R ShookAshok SrinivasanJohn ChoiRandall T HaydenWing Leung

Published in: Transplant infectious disease : an official journal of the Transplantation Society (2018)

CD45RA-depletion provided a large number of donor memory T cells to the recipients and was associated with enhanced early T-cell recovery and protection against viremia.

Keyphrases

rheumatoid arthritis
cancer therapy
nk cells
disease activity
ankylosing spondylitis
systemic lupus erythematosus
kidney transplantation