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The application of human periodontal ligament stem cells and biomimetic silk scaffold for in situ tendon regeneration.

Jialin ChenQingyun MoRenwang ShengAijing ZhuChen LingYifan LuoAini ZhangZhixuan ChenQingqiang YaoZhuoying CaiWei Zhang
Published in: Stem cell research & therapy (2021)
In summary, this study demonstrates the efficacy of hPDLSCs as seed cells and aligned silk scaffold as a tendon-mimetic scaffold for enhanced tendon tissue engineering, which may have broad implications for future tendon tissue engineering and regenerative medicine researches.
Keyphrases
  • tissue engineering
  • stem cells
  • anterior cruciate ligament reconstruction
  • rotator cuff
  • induced apoptosis
  • endothelial cells
  • bone marrow
  • endoplasmic reticulum stress
  • signaling pathway
  • cell death
  • wound healing