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Effect of β1 /β2 -adrenoceptor blockade on β3 -adrenoceptor activity in the rat cremaster muscle artery.

Samantha L SaundersDana Sabine HutchinsonFiona C BrittonLu LiuIrit MarkusShaun L SandowTimothy V Murphy
Published in: British journal of pharmacology (2021)
All three β-adrenoceptor subtypes were present in the endothelium of the rat cremaster muscle artery, but β3 -adrenoceptor mediated vasodilation was only evident after blockade of β1/2 -adrenoceptors. This suggests constitutive β1/2 -adrenoceptor activity inhibits β3 -adrenoceptor function in the endothelium of skeletal muscle resistance arteries.
Keyphrases
  • skeletal muscle
  • nitric oxide
  • oxidative stress
  • insulin resistance
  • type diabetes
  • adipose tissue
  • blood flow