A Distinct Chromatin State Drives Therapeutic Resistance in Invasive Lobular Breast Cancer.

Agostina Nardone Xintao Qiu Sándor Spisák Zsuzsanna Nagy Ariel Feiglin Avery Feit Gabriella Cohen Yingtian Xie Alba Font-Tello Cristina Guarducci Francisco Hermida-Prado Sudeepa Syamala Klothilda Lim Miguel Munoz Gomez Matthew Pun MacIntosh Grant Cornwell Weihan Liu Aysegul Ors Hisham Mohammed Paloma Cejas Jane B Brock Matthew L Freedman Eric P Winer Xiaoyong Fu Rachel Schiff Henry W Long Otto Metzger Filho Rinath M Jeselsohn

Published in: Cancer research (2022)

A unique FOXA1-ER axis in invasive lobular breast cancer promotes disease progression and tamoxifen resistance, highlighting a potential therapeutic avenue for clinical investigations dedicated to this disease. See related commentary by Blawski and Toska, p. 3668.

Keyphrases

estrogen receptor
breast cancer cells
gene expression
dna damage
genome wide
dna methylation
endoplasmic reticulum