Abnormal brain development in child and adolescent carriers of mutant huntingtin.
Ellen van der PlasDouglas R LangbehnAmy Lynn ConradTimothy R KoscikAlexander TereshchenkoEric A EppingVincent A MagnottaPeggy C NopoulosPublished in: Neurology (2019)
Our results suggest that pathogenesis of HD begins with abnormal brain development. An understanding of potential neurodevelopmental features associated with mHTT may be needed for optimized implementation of preventative gene silencing therapies, such that normal aspects of neurodevelopment are preserved as neurodegeneration is forestalled.