Brønsted Acid-Catalyzed Cascade Ring-Opening/Cyclization of 3-Ethoxy Cyclobutanones to Access 2,8-Dioxabicyclo[3.3.1]nonane Derivatives.

A cascade ring opening of 3-ethoxy cyclobutanones followed by a double cyclization strategy has been developed via Brønsted acid catalysis. A range of 2,8-dioxabicyclo[3.3.1]nonanes are obtained from various substituted naphthols in a one-pot and open flux manner. Additionally, a 15-membered macrocycle has been synthesized by ring closing metathesis as a synthetic application.