Cerebral amyloid angiopathy: Clinical Presentations and Management Challenges in the Australian Context.

Cerebral Amyloid angiopathy (CAA) is a disease with several clinical manifestations. It is characterized by amyloid beta deposition in cerebral blood vessels, making them prone to bleeding. The incidence of CAA increases with age and may be associated or co-exist with intraparenchymal neurodegenerative proteinopathies, which makes it an increasingly relevant condition for adult physicians in all areas of medical practice. The vast majority of cases of CAA are sporadic with a small minority of familial cases. CAA is asymptomatic in many older adults but increases the risk of fatal intracerebral or subarachnoid haemorrhage. We reviewed the existing literature on CAA and summarized the key findings. We specifically explore clinical challenges relevant to CAA, particularly in diagnosis, management of intracranial haemorrhage and management of concurrent medical conditions. This article is protected by copyright. All rights reserved.