Sex influences eQTL effects of SLE and Sjögren's syndrome-associated genetic polymorphisms.

Magdalena LindénJorge I Ramírez SepúlvedaTojo JamesGudny Ella ThorlaciusSusanna BraunerDavid Gómez-CabreroTomas OlssonIngrid KockumMarie Wahren-Herlenius

Published in: Biology of sex differences (2017)

We identified several unknown sex-specific eQTL effects of SLE/pSS-associated genetic polymorphisms and provide novel insight into how gene-sex interactions may contribute to the sex bias in systemic autoimmune diseases.

Keyphrases

systemic lupus erythematosus
disease activity
rheumatoid arthritis
copy number
dna methylation
transcription factor