Recurrent RhoGAP gene fusion CLDN18-ARHGAP26 promotes RHOA activation and focal adhesion kinase and YAP-TEAD signalling in diffuse gastric cancer.

Feifei ZhangVarun SahuKe PengYichen WangTianxia LiPratyusha BalaDaulet AitymbayevPranshu SahgalAntje SchaeferChanning J DerSandra RyeomSam YoonNilay S SethiAdam J BassHaisheng Zhang

Published in: Gut (2024)

fusion is a gain-of-function DGC oncogene that leads to activation of RHOA and activation of FAK and YAP signalling. These results argue for further evaluation of emerging FAK and YAP-TEAD inhibitors for these deadly cancers.

Keyphrases

cell migration
gene expression
escherichia coli
copy number
cystic fibrosis
transcription factor
dna methylation
young adults
protein kinase
genome wide analysis