Structurally abnormal collagen fibrils in abdominal aortic aneurysm resist platelet adhesion.
Blain JonesAnna DebskiChetan P HansMichael R GoGunjan AgarwalPublished in: Journal of thrombosis and haemostasis : JTH (2021)
Our investigations reveal how the collagen fibril structure in the vessel wall can serve as another regulator of platelet-collagen adhesion. These results can be broadly applied to understand the role of collagen fibril structure in regulating thrombosis or bleeding disorders.