Synchronous and metachronous liver metastases in patients with colorectal cancer-towards a clinically relevant definition.
Jennie EngstrandCecilia StrömbergHenrik NilssonJacob FreedmanEduard JonasPublished in: World journal of surgical oncology (2019)
Synchronous vs. metachronous detection of CRC liver metastases lacks prognostic value. Using primary tumour diagnosis/operation as standardized cut-off point to define synchronous/metachronous detection is semantically correct. In synchronous detection, it defines a clinically relevant group of patients where individualized multimodality treatment protocols will apply.