The Histogenetic Origin of Malignant Cells Predicts Their Susceptibility towards Synthetic Lethality Utilizing the TK.007 System.

Fabian Bernhard PallaschVera FreytagMalte KriegsDennis GatzemeierThomas MairHannah VossKristoffer RieckenMona DawoodBoris Fehse Thomas Efferth Hartmut SchlüterUdo Schumacher

Published in: Cancers (2024)

The histogenetic origin of cells influenced the susceptibility of human malignant cells towards cytotoxic agents with leukemias and lymphomas being more sensitive than solid cancer cells.

Keyphrases

induced apoptosis
cell cycle arrest
oxidative stress
cell proliferation