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Interaction of phages, bacteria, and the human immune system: Evolutionary changes in phage therapy.

Rizka O A JariahMohamad Saifudin Hakim
Published in: Reviews in medical virology (2019)
Phages and bacteria are known to undergo dynamic and co-evolutionary arms race interactions in order to survive. Recent advances from in vitro and in vivo studies have improved our understanding of the complex interactions between phages, bacteria, and the human immune system. This insight is essential for the development of phage therapy to battle the growing problems of antibiotic resistance. It is also pivotal to prevent the development of phage-resistance during the implementation of phage therapy in the clinic. In this review, we discuss recent progress of the interactions between phages, bacteria, and the human immune system and its clinical application for phage therapy. Proper phage therapy design will ideally produce large burst sizes, short latent periods, broad host ranges, and a low tendency to select resistance.
Keyphrases
  • pseudomonas aeruginosa
  • endothelial cells
  • primary care
  • healthcare
  • stem cells
  • mental health
  • induced pluripotent stem cells
  • genome wide
  • gene expression
  • cystic fibrosis
  • dna methylation
  • high frequency
  • cell therapy