Effects of heat-killed Lactiplantibacillus plantarum TWK10 on exercise performance, fatigue, and muscle growth in healthy male adults.
Yi-Chen ChengChia-Chia LeeMon-Chien LeeHan-Yin HsuJin-Seng LinChi-Chang HuangKoichi WatanabePublished in: Physiological reports (2023)
Consumption of Lactiplantibacillus plantarum TWK10 (TWK10) has beneficial probiotic effects, improves exercise endurance performance, regulates body composition, and mitigates aging-related problems in mice and humans. Here, we investigated the effects of heat-killed TWK10 on exercise endurance performance, muscle weight and strength, fatigue, and body composition in a double-blind, placebo-controlled clinical trial. Thirty healthy males aged 20-40 years were assigned to the Control group or heat-killed TWK10 group (TWK10-HK) in a balanced order according to each individual's initial maximal oxygen uptake. After 6-week administration, the exercise endurance time in the TWK10-HK was significantly increased (p = 0.0028) compared with that in the Control group. The grip strength on the right and left hands of the subjects was significantly increased (p = 0.0002 and p = 0.0140, respectively) in the TWK10-HK compared with that in the Control group. Administration of heat-killed TWK10 resulted in a significant increase (p = 0.0275) in muscle weight. After 6-week administration, serum lactate, and ammonia levels were significantly lower in the TWK10-HK group than in the Control group during the exercise and recovery periods. These findings demonstrate that heat-killed TWK10 has significant potential to be used as a postbiotic for humans.
Keyphrases
- mass spectrometry
- resistance training
- body composition
- high intensity
- skeletal muscle
- physical activity
- clinical trial
- heat stress
- bone mineral density
- high glucose
- body mass index
- weight loss
- placebo controlled
- mental health
- squamous cell carcinoma
- depressive symptoms
- blood pressure
- study protocol
- risk assessment
- metabolic syndrome
- postmenopausal women
- rectal cancer