Human neural stem cells restore spatial memory in a transgenic Alzheimer's disease mouse model by an immunomodulating mechanism.
Kevin S ChenMohamed H NoureldeinLisa M McGinleyJohn M HayesDiana M RiganJacquelin F KwentusShayna N MasonFaye E MendelsonMasha Georges SavelieffEva L FeldmanPublished in: bioRxiv : the preprint server for biology (2023)
hNSCs normalized many dysregulated genes, although this was not mediated by a change in amyloid plaque levels. Rather, hNSCs appear to exert beneficial effects in part by modulating microglia-mediated neuroinflammation and signaling in AD.
Keyphrases
- neural stem cells
- mouse model
- endothelial cells
- traumatic brain injury
- inflammatory response
- coronary artery disease
- working memory
- genome wide
- lipopolysaccharide induced
- cognitive decline
- signaling pathway
- lps induced
- neuropathic pain
- spinal cord injury
- spinal cord
- mild cognitive impairment
- cerebral ischemia
- subarachnoid hemorrhage