Pharmacometabolomics reveals a role for histidine, phenylalanine, and threonine in the development of paclitaxel-induced peripheral neuropathy.
Yihan SunJae Hyun KimKiran VangipuramDaniel F HayesEllen M L SmithLarisa YeomansN Lynn HenryKathleen A StringerDaniel Louis HertzPublished in: Breast cancer research and treatment (2018)
Whole blood metabolomics is a feasible approach to identify potential biomarker candidates of paclitaxel-induced PN. The findings suggest that pretreatment concentrations of histidine, phenylalanine, and threonine may be predictive of the severity of future PN and paclitaxel-induced metabolic changes may be related to disruption of energy homeostasis.