Exploring the Therapeutic Potential of Triptonide in Salivary Adenoid Cystic Carcinoma: A Comprehensive Approach Involving Network Pharmacology and Experimental Validation.

Shikai GengLi ChenWanzun LinFangzhu WanZiyu LeWei HuHuaiyuan ChenXingyu LiuQingting HuangHaojiong ZhangJiade J LuLin Kong

Published in: Current pharmaceutical design (2024)

There is a potential therapeutic role for TN in the treatment of ACC through the activation of the TNF signaling pathway. Among the identified candidates, MAPK8, HDAC1, PTGS2, RELA, NR3C1, PPARG, NFKBIA, AR, and PGR emerge as the most pertinent therapeutic targets for TN in the context of ACC treatment.

Keyphrases

signaling pathway
pi k akt
rheumatoid arthritis
oxidative stress
epithelial mesenchymal transition
replacement therapy
histone deacetylase
network analysis