HPV16-E6 Oncoprotein Activates TGF-β and Wnt/β-Catenin Pathways in the Epithelium-Mesenchymal Transition of Cataracts in a Transgenic Mouse Model.
Genaro Rodríguez-UribeNicolás Addiel Serafín-HigueraGabriela Damian-MoralesEnoc Mariano Cortés-MalagónVicky García-HernándezOdette Verdejo-TorresJessica Paulina Campos-BlázquezCynthia R Trejo-MuñozRubén Gerardo ContrerasRodolfo Ocadiz-DelgadoCarmen Palacios-ReyesPaul F LambertAnne E GriepTeresa Mancilla-PercinoJaime Escobar-HerreraElizabeth Álvarez-RíosCarlos Ugarte-BrionesJosé MorenoPatricio GariglioJosé Bonilla-DelgadoPublished in: BioMed research international (2018)
The HPV16-E6 oncoprotein induces EMT in transgenic mice cataracts. The molecular mechanism may involve TGF-β and Wnt/β-catenin pathways, suggesting that the K14E6 transgenic mouse could be a useful model for the study or treatment of EMT-induced cataracts.