Association Between the Phenotype and Genotype of Isoniazid Resistance Among Mycobacterium tuberculosis Isolates in Thailand.

Ratchanu CharoenpakWichai SantimaleeworagunGompol SuwanpimolkulWeerawat ManosuthiPaweena KongsananSuthidee Petsong Chankit Puttilerpong

Published in: Infection and drug resistance (2020)

Most HR-TB isolates had high isoniazid-resistance levels associated with the katG gene mutation. High-dose isoniazid should be used with caution in patients with HR-TB. Early detection of drug resistance by genotypic assay can help determine an appropriate regimen.

Keyphrases

mycobacterium tuberculosis
high dose
pulmonary tuberculosis
genetic diversity
low dose
high throughput
stem cell transplantation
single cell