Abdominal surgery may impair hippocampal spatial memory, possibly through the HDAC6-triggered increase in the function of HSP90, consequently strengthening the negative role of steroids in cognitive function. Targeting HDAC6- HSP90/GR signaling may provide a potential avenue for the treatment of the impairment of cognitive function after surgery.
Keyphrases
- histone deacetylase
- heat shock protein
- heat shock
- heat stress
- signaling pathway
- cardiac surgery
- middle aged
- working memory
- patients undergoing
- epithelial mesenchymal transition
- type diabetes
- oxidative stress
- cell proliferation
- drug delivery
- risk assessment
- human health
- skeletal muscle
- adipose tissue
- subarachnoid hemorrhage
- temporal lobe epilepsy