Ex vivo susceptibility to antimalarial drugs and polymorphisms in drug resistance genes of African Plasmodium falciparum , 2016-2023: a genotype-phenotype association study.

Jason RosadoAbebe A FolaSandrine CojeanVéronique SarrasinRomain CoppéeRizwana ZaffaroulahAzza BouzayeneLiliane CicéronLudivine HouzéRebecca CrudaleLise MussetMarc ThellierBruno PradinesJérôme ClainJeffrey A BaileySandrine Houzénull null

Published in: medRxiv : the preprint server for health sciences (2024)

isolates from West and Central Africa. While the data suggests that ACTs and sulfadoxine-pyrimethamine are likely to be effective in these regions, the phenotypic changes we observed call for intensifying the monitoring of antimalarial drug resistance in Africa.

Keyphrases

plasmodium falciparum
genome wide
drug induced
transcription factor
data analysis