APR-246 induces apoptosis and enhances chemo-sensitivity via activation of ROS and TAp73-Noxa signal in oesophageal squamous cell cancer with TP53 missense mutation.
Teruyuki KobayashiTomoki MakinoKotaro YamashitaTakuro SaitoKoji TanakaTsuyoshi TakahashiYukinori KurokawaMakoto YamasakiKiyokazu NakajimaEiichi MoriiHidetoshi EguchiYuichiro DokiPublished in: British journal of cancer (2021)
APR-246 strongly induced apoptosis by inducing ROS activity and p73-Noxa signalling, specifically in ESCC with p53 missense mutation. This antitumour effect was further enhanced by combination with 5-FU, which we first confirmed in ESCC preclinical model.
Keyphrases
- squamous cell
- induced apoptosis
- endoplasmic reticulum stress
- intellectual disability
- signaling pathway
- oxidative stress
- dna damage
- cell death
- reactive oxygen species
- photodynamic therapy
- papillary thyroid
- stem cells
- autism spectrum disorder
- cell therapy
- combination therapy
- radiation therapy
- mesenchymal stem cells
- squamous cell carcinoma
- drug delivery
- young adults
- childhood cancer