Clinical Pharmacokinetics and Dose Recommendations for Posaconazole in Infants and Children.
Sophida BoonsathornIek ChengFrank KloproggeCarlos AlonsoCharmion LeeBilyana DonchevaJohn BoothRobert ChiesaAdam IrwinJoseph F StandingPublished in: Clinical pharmacokinetics (2020)
In the largest population-pharmacokinetic study to date in children, we have found similar covariate effects to those seen in adults, but low bioavailability of suspension in patients with diarrhoea or those taking concurrent proton pump inhibitors, which may in particular limit the use of posaconazole in these patients.