The impact of cardiovascular co-morbidities and duration of diabetes on the association between microvascular function and glycaemic control.

In those with T2DM and CVD, good glycaemic control is still associated with better microvascular function, whereas in those with prolonged disease this association is lost. This suggests duration of diabetes may be a better surrogate for "advanced disease" than concomitant CVD, although this requires prospective validation.