Mutant p53 gain of function mediates cancer immune escape that is counteracted by APR-246.

Xiaolei ZhouGema Sanz SantosYue ZhanMariana M S OliveiraShiva RezaeiMadhurendra SinghSylvain PeugetLisa S Westerberg John Inge Johnsen Galina Selivanova

Published in: British journal of cancer (2022)

Breast carcinomas with mtp53 displayed enhanced inflammation. APR-246 boosted the interferon response or represses immune checkpoints in p53 mutant tumour cells, and restores cancer immune surveillance in vivo.

Keyphrases

papillary thyroid
squamous cell
induced apoptosis
oxidative stress
public health
squamous cell carcinoma
cell cycle arrest
childhood cancer
immune response
pi k akt