Protective mechanism of artemisinin on rat bone marrow-derived mesenchymal stem cells against apoptosis induced by hydrogen peroxide via activation of c-Raf-Erk1/2-p90rsk-CREB pathway.

Jiankang FangXia ZhaoShuai LiXingan XingHaitao WangPhilip LazaroviciWenhua Zheng

Published in: Stem cell research & therapy (2019)

These studies demonstrate the proof of concept of artemisinin therapeutic potential to improve survival in vitro of BMSCs exposed to ROS-induced apoptosis and suggest that artemisinin-mediated protection occurs via the activation of c-Raf-Erk1/2-p90rsk-CREB signaling pathway.

Keyphrases

signaling pathway
induced apoptosis
hydrogen peroxide
pi k akt
endoplasmic reticulum stress
oxidative stress
plasmodium falciparum
bone marrow
cell cycle arrest
epithelial mesenchymal transition
cell death
nitric oxide
dna damage
mesenchymal stem cells
cell proliferation
reactive oxygen species
free survival