Perturbations in common and distinct inflammatory pathways associated with morning and evening fatigue in outpatients receiving chemotherapy.

Kord M Kober Carolyn S Harris Yvette P Conley Anand A DhruvaVasuda DokiparthiMarilyn J Hammer Jon D Levine Kate R OppegaardSteven PaulJoosun ShinAnatol SucherFay WrightBrian YuenAdam B Olshen Christine A Miaskowski

Published in: Cancer medicine (2022)

This study describes perturbations in common and distinct inflammatory pathways associated with morning and/or evening fatigue. PI3K-Akt was identified as a bottleneck pathway. The analysis identified potential targets for therapeutic interventions for this common and devastating clinical problem.

Keyphrases

pi k akt
signaling pathway
cell proliferation
cell cycle arrest
oxidative stress
sleep quality
cell death
rectal cancer