Laser-facilitated epicutaneous immunotherapy with hypoallergenic beta-glucan neoglycoconjugates suppresses lung inflammation and avoids local side effects in a mouse model of allergic asthma.

Evgeniia KorotchenkoViktoria SchießlSandra ScheiblhoferMario SchubertElfriede DallIsabella A JoubertHelen StrandtTheresa NeuperMuamera SarajlicRenate BauerMark GeppertDavid JoedickeSabrina WildnerSusanne SchallerStephan WinklerGabriele GadermaierJutta Horejs-HoeckRichard Weiss

Published in: Allergy (2020)

Conjugation of ovalbumin to laminarin increased its immunogenicity while at the same time reducing local side effects. LamOVA EPIT via laser-generated micropores is safe and equally effective compared to SCIT with alum, without the need for adjuvant.

Keyphrases

mouse model
allergic rhinitis
oxidative stress
chronic obstructive pulmonary disease
early stage
high speed
signaling pathway
lung function
cystic fibrosis
mass spectrometry