Wnt pathway-related three-mRNA clinical outcome signature in bladder urothelial carcinoma: computational biology and experimental analyses.
Siqing SunYutao WangJianfeng WangJianbin BiPublished in: Journal of translational medicine (2021)
We found that Wnt signaling pathway-related genes can be used as prognostic risk factors for BLCA, and the Wnt signaling pathway is a cancer-promoting signaling pathway associated with EMT. We identified three critical genes: MAPK10, RAC3, and PPP2CB. The genes in these three Wnt signaling pathways are associated with tumor cell EMT and immune cell infiltration. The most important finding was that these three genes were independent prognostic factors for BLCA.
Keyphrases
- signaling pathway
- epithelial mesenchymal transition
- pi k akt
- cell proliferation
- prognostic factors
- stem cells
- induced apoptosis
- genome wide
- genome wide identification
- bioinformatics analysis
- spinal cord injury
- papillary thyroid
- cell therapy
- single cell
- gene expression
- oxidative stress
- genome wide analysis
- dna methylation
- binding protein
- young adults
- squamous cell
- lymph node metastasis