A dual role of miR-22 in rhabdomyolysis-induced acute kidney injury.

S MathiaL J RudigierM KasimKarin M KirschnerP B PerssonK-U EckardtChristian RosenbergerM Fähling

Published in: Acta physiologica (Oxford, England) (2018)

miR-22 is a HIF repressor constitutively expressed in the adult kidney and up-regulated in AKI. Specific inhibition of miR-22 is efficient in vivo and profoundly affects renal gene expression in health and disease, including up-regulation of HIF. However, the net effect on rhabdomyolysis-induced AKI outcome is neutral or even negative.

Keyphrases

acute kidney injury
cell proliferation
cardiac surgery
long non coding rna
gene expression
long noncoding rna
high glucose
diabetic rats
endothelial cells
public health
drug induced
dna methylation
transcription factor
mental health
health information
social media
risk assessment
health promotion