A rapid and flexible microneutralization assay for serological assessment of influenza viruses.
Kalee E RumfeltWilliam J FitzsimmonsRachel TrusconArnold S MontoEmily T MartinAdam S LauringPublished in: Influenza and other respiratory viruses (2023)
The LMN assay was feasible using limited sample volumes and able to differentiate small antigenic differences between egg-adapted and cell-derived strains. The correspondence of these results with the commonly used HAI confirms the utility of this assay for high-throughput studies of correlates of protection and vaccine response.