A rapid and flexible microneutralization assay for serological assessment of influenza viruses.

Kalee E RumfeltWilliam J FitzsimmonsRachel TrusconArnold S MontoEmily T Martin Adam S Lauring

Published in: Influenza and other respiratory viruses (2023)

The LMN assay was feasible using limited sample volumes and able to differentiate small antigenic differences between egg-adapted and cell-derived strains. The correspondence of these results with the commonly used HAI confirms the utility of this assay for high-throughput studies of correlates of protection and vaccine response.

Keyphrases

high throughput
single cell
escherichia coli
case control
loop mediated isothermal amplification
quantum dots
genetic diversity
sensitive detection