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A rapid and flexible microneutralization assay for serological assessment of influenza viruses.

Kalee E RumfeltWilliam J FitzsimmonsRachel TrusconArnold S MontoEmily T MartinAdam S Lauring
Published in: Influenza and other respiratory viruses (2023)
The LMN assay was feasible using limited sample volumes and able to differentiate small antigenic differences between egg-adapted and cell-derived strains. The correspondence of these results with the commonly used HAI confirms the utility of this assay for high-throughput studies of correlates of protection and vaccine response.
Keyphrases
  • high throughput
  • single cell
  • escherichia coli
  • case control
  • loop mediated isothermal amplification
  • quantum dots
  • genetic diversity
  • sensitive detection