Identification of DNA methylation markers for early detection of CRC indicates a role for nervous system-related genes in CRC.

Glenn RademakersMaartje MassenAlexander KochMuriel X DrahtNikkie BuekersKim A D WoutersNathalie VaesTim De MeyerBeatriz CarvalhoGerrit A MeijerJames G HermanKim M SmitsManon van EngelandVeerle Melotte

Published in: Clinical epigenetics (2021)

In silico discovery analysis using TCGA-derived data yielded a novel DNA-methylation-based assay for the early detection of CRC, potentially improving current screening modalities. Additionally, nervous system-related pathways were enriched in the identified genes, indicating an epigenetic regulation of neuronal genes in CRC.

Keyphrases

dna methylation
genome wide
bioinformatics analysis
gene expression
high throughput
small molecule
copy number
genome wide identification
genome wide analysis
machine learning
artificial intelligence
brain injury
single cell