A low-molecular-weight compound exerts anticancer activity against breast and lung cancers by disrupting EGFR/Eps8 complex formation.

Meifang LiJilong YangLenghe ZhangSanfang TuXuan ZhouZe TanWeijun ZhouYanjie HeYuhua Li

Published in: Journal of experimental & clinical cancer research : CR (2019)

We identified EE02 as an EGFR/Eps8 complex inhibitor that demonstrated promising antitumor effects in breast cancer and NSCLC. Our data suggest that the EGFR/Eps8 complex offers a novel cancer drug target.

Keyphrases

small cell lung cancer
epidermal growth factor receptor
tyrosine kinase
advanced non small cell lung cancer
brain metastases
papillary thyroid
electronic health record
squamous cell carcinoma
squamous cell
childhood cancer
emergency department
deep learning
artificial intelligence