Stereoselective conjugate addition of ketones to alkylidene malonates using thiourea-sulfonamide organocatalyst.
Masahiro KawadaKosuke NakashimaShin-Ichi HirashimaToru SakagamiYuji KosekiTsuyoshi MiuraPublished in: Chirality (2018)
In this study, stereoselective conjugate addition of ketones to alkylidene malonates using organocatalyst has been developed. The reaction in the presence of 20 mol% of a novel thiourea-sulfonamide organocatalyst afforded conjugate adducts in moderate to high yields (up to 81%) under mild reaction conditions. Excellent diastereoselectivity (up to 98:2 dr) and enantioselectivity (up to 88% ee) were achieved.
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