Time-Course Changes and New Expressions of MIP-3α and Its Receptor, CCR6, in the Gerbil Hippocampal CA1 Area Following Transient Global Cerebral Ischemia.
Joon Ha ParkYooHun NohSung-Su KimJi Hyeon AhnTaek Geun OhkJun Hwi ChoTae-Kyeong LeeHyunjung KimMinah SongJae-Chul LeeMoo-Ho WonChoong-Hyun LeePublished in: Neurochemical research (2018)
Macrophage inflammatory protein-3α (MIP-3α) and its sole receptor, CCR6, play pivotal roles in neuroinflammatory processes induced by brain ischemic insults. In this study, we investigated transient ischemia-induced changes in MIP-3α and CCR6 protein expressions in the hippocampal CA1 area following 5 min of transient global cerebral ischemia (tgCI) in gerbils. Both MIP-3α and CCR6 immunoreactivities were very strongly expressed in pyramidal neurons of the CA1 area from 6 h to 1 day after tgCI and were hardly shown 4 days after tgCI. In addition, strong MIP-3α immunoreactivity was newly expressed in astrocytes 6 h after tgCI. These results indicate that tgCI causes apparent changes in MIP-3α and CCR6 expressions in pyramidal neurons and astrocytes in the hippocampal CA1 area and suggest that tgCI-induced changes in MIP-3α and CCR6 expressions might be closely associated with neuroinflammatory processes in brain ischemic regions.
Keyphrases
- cerebral ischemia
- subarachnoid hemorrhage
- blood brain barrier
- brain injury
- dendritic cells
- regulatory t cells
- spinal cord
- binding protein
- protein kinase
- protein protein
- immune response
- adipose tissue
- multiple sclerosis
- magnetic resonance
- small molecule
- mass spectrometry
- atomic force microscopy
- resting state
- high resolution