Impact of a purified microbiome therapeutic on abundance of antimicrobial resistance genes in patients with recurrent Clostridioides difficile infection.

Timothy J StraubMary-Jane LombardoJessica A BryantLiyang DiaoThomas P LodiseDaniel E FreedbergJennifer WortmanKevin D LitcofskyBrooke R HassonBarbara H McGovernChristopher B FordMatthew R Henn

Published in: Clinical infectious diseases : an official publication of the Infectious Diseases Society of America (2023)

This proof-of-concept analysis suggests that microbiome remodeling with Firmicutes spores may be a potential novel approach to reduce ARG colonization in the gastrointestinal tract.

Keyphrases

antimicrobial resistance
clostridium difficile
gene expression
risk assessment
transcription factor
wastewater treatment