Impact of age and apolipoprotein E ε4 status on regional white matter hyperintensity volume and cognition in healthy aging.
Emily J Van EttenPradyumna K BharadwajMatthew D GrilliDavid A RaichlenGeorg A HishawMatthew J HuentelmanTheodore P TrouardGene E AlexanderPublished in: Journal of the International Neuropsychological Society : JINS (2024)
These findings suggest that, among healthy young-old adults, increased left temporal WMH volume, in the context of the ε4 allele, may represent an early marker of cognitive aging with the potential to lead to greater risk for AD.