Association of Presynaptic Loss with Alzheimer's Disease and Cognitive Decline.
Guoyu LanYue CaiAnqi LiZhen LiuShaohua MaTengfei Guonull nullPublished in: Annals of neurology (2022)
Tau aggregations rather than Aβ plaques primarily drive presynaptic dysfunction measured by CSF GAP43, which may lead to sequential neurodegeneration and cognitive impairment in AD or neurodegenerative diseases. ANN NEUROL 2022;92:1001-1015.