Cd34 Immunostaining Adds Specificity To Microvascular invasion Analysis in Hepatocellular Carcinoma.
Henrique GamaRonniel AlbuquerqueDavid Campos WanderleyMarcelo Antônio Pascoal XavierFernanda Maria Farage OsórioCláudia Alves CoutoTeresa Cristina de Abreu FerrariAgnaldo S LimaPaulo Henrique Costa DinizPaula Vieira Teixeira VidigalPublished in: Journal of hepatocellular carcinoma (2023)
Intraobserver higher agreement allows us to suppose that pathologists employed own criteria to evaluate vascular invasion, reinforcing the need of standardization. ROC Curves analysis showed that the CD34 method is more specific than sensitive. Therefore, immunohistochemistry for CD34 should not be used routinely, but it could be useful to help confirming invasion previously seen by conventional histology.
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