Alleviation of Liver Dysfunction, Oxidative Stress and Inflammation Underlies the Protective Effect of Ferulic Acid in Methotrexate-Induced Hepatotoxicity.
Mozhdeh RoghaniHeibatullah KalantariMohammad Javad KhodayarLayasadat KhorsandiMojtaba KalantarMehdi GoudarziHadi KalantarPublished in: Drug design, development and therapy (2020)
Based on our findings, oxidative stress impairment and MTX-induced liver damage were ameliorated following FA pretreatment at both histological and biochemical levels. Therefore, FA can be effectively used in abrogation of MTX-induced toxicity.