Impact on spina bifida screening of shifting prenatal Down syndrome maternal serum screening from the second trimester to the first.
Emmanuel SpaggiariSophie DreuxJulien J StirnemannIsabelle CzerkiewiczVéronique Houfflin-DebargeAlexandra SegonneJean-Marie JouannicYves VilleFrancoise MullerPublished in: Prenatal diagnosis (2017)
Loss of maternal serum alpha-fetoprotein had a tangible effect on the gestational age at diagnosis of spina bifida and resulted in a decrease of 25% of cases of spina bifida detected before 20 weeks. © 2017 John Wiley & Sons, Ltd.