In Silico Analysis Predicts Nuclear Factors NR2F6 and YAP1 as Mesenchymal Subtype-Specific Therapeutic Targets for Ovarian Cancer Patients.

Wanja KassuhnPedro Rodriguez Cutillas Mirjana Kessler Jalid SehouliElena I BraicuNils BlüthgenHagen Kulbe

Published in: Cancers (2023)

By utilizing a sophisticated bioinformatics approach, several candidates for treatment opportunities, including YAP1 and NR2F6 were identified. These candidates represent signalling regulators within the cellular network of the MES. Hence, further studies to confirm these candidates as potential targeted therapies in PM are warranted.

Keyphrases

end stage renal disease
newly diagnosed
chronic kidney disease
ejection fraction
stem cells
peritoneal dialysis
bone marrow
air pollution
transcription factor
patient reported outcomes
molecular docking
heavy metals
human health
patient reported
case control
network analysis