Multiomics identifies the link between intratumor steatosis and the exhausted tumor immune microenvironment in hepatocellular carcinoma.

Hiroki MuraiTakahiro KodamaKazuki MaesakaShoichiro TangeDaisuke MotookaYutaka SuzukiYasuyuki ShigematsuKentaro InamuraYoshihiro MiseAkio SaiuraYoshihiro OnoYu TakahashiYota KawasakiSatoshi IinoShogo KobayashiMasashi IdogawaTakashi TokinoTomomi Hashidate-YoshidaHideo ShindouMasanori MiyazakiYasuharu ImaiSatoshi TanakaEiji MitaKazuyoshi OhkawaHayato HikitaRyotaro SakamoriTomohide TatsumiHidetoshi EguchiEiichi MoriiTetsuo Takehara

Published in: Hepatology (Baltimore, Md.) (2022)

Multiomics stratified nonviral HCCs according to prognosis or TIME. We identified the link between intratumoral steatosis and immune-exhausted immunotherapy-susceptible TIME.

Keyphrases

insulin resistance
high fat diet
high fat diet induced
stem cells
genome wide
adipose tissue
metabolic syndrome
type diabetes
skeletal muscle