Stacked Gold Nanodisks for Bimodal Photoacoustic and Optical Coherence Imaging.
Jung-Sub WiJisoo ParkHeesung KangDonggeun JungSang-Won LeeTae Geol LeePublished in: ACS nano (2017)
Herein, we report on biological imaging nanoprobes: physically synthesized gold nanodisks that have inherent optical advantages-a wide range of resonant wavelengths, tunable ratio of light absorption-to-scattering, and responsiveness to random incident light-due to their two-dimensional circular nanostructure. Based on our proposed physical synthesis where gold is vacuum deposited onto a prepatterned polymer template and released from the substrate in the form of a nanodisk, monodisperse two-dimensional gold nanodisks were prepared with independent control of their diameter and thickness. The optical benefits of the Au nanodisk were successfully demonstrated by the measurement of light absorbance of the nanodisks and the application of stacked nanodisks, where a smaller sized Au nanodisk was laid atop a larger nanodisk, as bimodal contrast agents for photoacoustic microscopy and optical coherence tomography.
Keyphrases
- high resolution
- optical coherence tomography
- high speed
- fluorescence imaging
- silver nanoparticles
- sensitive detection
- cardiovascular disease
- mental health
- magnetic resonance
- mass spectrometry
- diabetic retinopathy
- optic nerve
- computed tomography
- reduced graphene oxide
- photodynamic therapy
- energy transfer
- magnetic resonance imaging
- tandem mass spectrometry
- single cell
- contrast enhanced
- quantum dots
- label free