Profile of copper-associated DNA methylation and its association with incident acute coronary syndrome.

Pinpin LongQiuhong WangYizhi ZhangXiaoyan ZhuKuai YuHaijing JiangXuezhen LiuMin ZhouYu YuanKang LiuJing JiangXiaomin ZhangMeian HeHuan GuoWeihong ChenJing YuanLongxian ChengLiming LiangTangchun Wu

Published in: Clinical epigenetics (2021)

We identified novel DNA methylation alterations associated with plasma Cu in Chinese populations and linked these loci to risk of ACS, providing new insights into the regulation of gene expression by Cu-related DNA methylation and suggesting a role for DNA methylation in the association between copper and ACS.

Keyphrases

dna methylation
acute coronary syndrome
gene expression
genome wide
percutaneous coronary intervention
antiplatelet therapy
copy number
cardiovascular disease
coronary artery disease
oxide nanoparticles
metal organic framework