Analysis of immune-related loci identifies 48 new susceptibility variants for multiple sclerosis.
null nullAshley H BeechamNikolaos A PatsopoulosDionysia K XifaraMary F DavisAnu KemppinenChris CotsapasTejas S ShahChris SpencerDavid BoothAn GorisAnnette OturaiJanna SaarelaBertrand FontaineBernhard HemmerClaes MartinFrauke ZippSandra D'AlfonsoFilippo Martinelli-BoneschiBruce TaylorHanne F HarboIngrid KockumJan HillertTomas OlssonMaria BanJorge R OksenbergRogier HintzenLisa F Barcellosnull nullnull nullCristina AgliardiLars AlfredssonMehdi AlizadehCarl AndersonRobert AndrewsHelle Bach SøndergaardAmie BakerGavin BandSergio E BaranziniNadia BarizzoneJeffrey C BarrettCéline BellenguezLaura BergamaschiLuisa BernardinelliAchim BertheleViola BiberacherThomas M C BinderHannah BlackburnIzaura L BomfimPaola BrambillaSimon BroadleyBruno BrochetLou BrundinDorothea BuckHelmut ButzkuevenStacy J CaillierWilliam CamuWassila CarpentierPaola CavallaElisabeth G CeliusIrène ComanGiancarlo ComiLucia CorradoLeentje CosemansIsabelle Cournu-RebeixBruce A C CreeDaniele CusiVincent DamotteGilles DeferSilvia R DelgadoPanos DeloukasAlessia di SapioAlexander T DiltheyPeter DonnellyBénédicte DuboisMartin DuddySarah EdkinsIrina ElovaaraFederica EspositoNikos EvangelouBarnaby FiddesJudith FieldAndre FrankeColin FreemanIrene Y FrohlichDaniela GalimbertiChristian GiegerPierre-Antoine GourraudChristiane GraetzAndrew GrahamVerena GrummelClara GuaschinoAthena HadjixenofontosHakon HakonarsonChristopher HalfpennyGillian HallPer HallAnders HamstenJames HarleyTimothy HarrowerClive HawkinsGarrett HellenthalCharles HillierJeremy HobartMuni HoshiSarah E HuntMaja JagodicIlijas JelčićAngela JochimBrian KendallAllan KermodeTrevor KilpatrickKeijo KoivistoIoanna KonidariThomas KornHelena KronsbeinCordelia LangfordMalin LarssonMark LathropChristine Lebrun-FrenayJeannette Lechner-ScottMichelle H LeeMaurizio A LeoneVirpi LeppäGiuseppe LiberatoreBenedicte A LieChristina M LillMagdalena LindénJenny LinkFelix LuessiJan LyckeFabio MacciardiSatu MännistöClara P ManriqueRoland MartinVittorio MartinelliDeborah MasonGordon MazibradaCristin McCabeInger-Lise MeroJulia MescheriakovaLoukas MoutsianasKjell-Morten MyhrGuy NagelsRichard NicholasPetra NilssonFredrik PiehlMatti PirinenSiân E PriceHong QuachMauri ReunanenWim RobberechtNeil P RobertsonMariaemma RodegherDavid RogMarco SalvettiNathalie C Schnetz-BoutaudFinn SellebjergRebecca C SelterCatherine SchaeferSandip ShaunakLing ShenSimon ShieldsVolker SiffrinMark SleePer Soelberg SorensenMelissa SorosinaMireia SospedraAnne SpurklandAmy StrangeEmilie SundqvistVincent ThijsJohn ThorpeAnna TiccaPentti TienariCornelia van DuijnElizabeth M VisserSteve VucicHelga WesterlindJames S WileyAlastair WilkinsJames F WilsonJuliane WinkelmannJohn ZajicekEva ZindlerJonathan L HainesMargaret A Pericak-VanceAdrian J IvinsonGraeme StewartDavid HaflerStephen L HauserAlastair CompstonGil McVeanPhilip De JagerStephen J SawcerJacob L McCauleyPublished in: Nature genetics (2013)
Using the ImmunoChip custom genotyping array, we analyzed 14,498 subjects with multiple sclerosis and 24,091 healthy controls for 161,311 autosomal variants and identified 135 potentially associated regions (P < 1.0 × 10(-4)). In a replication phase, we combined these data with previous genome-wide association study (GWAS) data from an independent 14,802 subjects with multiple sclerosis and 26,703 healthy controls. In these 80,094 individuals of European ancestry, we identified 48 new susceptibility variants (P < 5.0 × 10(-8)), 3 of which we found after conditioning on previously identified variants. Thus, there are now 110 established multiple sclerosis risk variants at 103 discrete loci outside of the major histocompatibility complex. With high-resolution Bayesian fine mapping, we identified five regions where one variant accounted for more than 50% of the posterior probability of association. This study enhances the catalog of multiple sclerosis risk variants and illustrates the value of fine mapping in the resolution of GWAS signals.