Development of CAR-T cells specifically targeting cancer stem cell antigen DNAJB8 against solid tumours.

Yuto Watanabe Tomohide TsukaharaKenji MurataShuto HamadaTerufumi KuboTakayuki KanasekiYoshihiko HirohashiMakoto EmoriAtsushi TeramotoMunehide NakatsugawaToshihiko YamashitaToshihiko Torigoe

Published in: British journal of cancer (2022)

B10 CAR-T cells could show specific cytotoxicity against RCC and osteosarcoma cells in vitro and in vivo. B10 CAR-T cells targeting the CSC/CIC antigen DNAJB8 might be a candidate immunotherapy for carcinoma and sarcoma.

Keyphrases

induced apoptosis
cell cycle arrest
cancer stem cells
cancer therapy
endoplasmic reticulum stress
signaling pathway
cell death
oxidative stress
drug delivery