Two-Year Observational Study of Autonomic Skin Function in Patients with Parkinson's Disease Compared to Healthy Individuals.
Timo SiepmannMartin ArndtAnnahita SedghiSzabolcs SzatmáriTamás HorváthAnnamária TakátsDániel BereczkiMats Leif MoskoppSylvia BuchmannCornelia SkowronekWagner ZagoWarunya WoranushRazvan LapuskaMarie Luise WeidemannChristopher GibbonsRoy FreemanHeinz ReichmannVolker PuetzKristian BarlinnAlexandra PintérBen Min-Woo IlligensPublished in: European journal of neurology (2023)
Impairment of adrenergic sympathetic pilomotor function and SSR in evolving PD is not paralleled by changes to cholinergic sudomotor function and parasympathetic neurocardiac function, suggesting a sympathetic pathophysiology. Pilomotor axon-reflex test might be useful to monitor PD-related pathology.